Description
The preparative SFC system is used for large scale purification using columns with IDs of 10, 20, and 30 mm. The system can be used for multiple sample library purification or individual component large-scale purification, with sample injection either using a preparative autosampler or syringe based large volume injector. Fraction collection can be triggered based on time, threshold or slope from up to 4 different detector signals including PDA, UV, CD, and/or MS. The flexible fraction layout includes open-bed fraction collection for a larger number of fractions for multiple samples or valve based with up to 8 fractions for repeated injections producing large fraction volumes. ChromNAV provides complete integrated control for flow rate, temperature, sample injection and fractionation. The SFC-4000 Preparative systems can be used for purifications using 10mm, 20mm or 30mm ID columns. The flexible configuration can be easily changed to suit a basic single column/single detector system or a multi-column/multi-detector system. Fraction collection options range from simple time-based 6 or 8 fractions to sophisticated threshold based open-bed fraction collection for up to 80 fractions. System control provides simple acquisition of chromatograms, automated data analysis, manual and automated fraction collection and a method scouting module for fast solvent and column screening.