Crissy Automated Screening Platform from Zinsser North America

Crissy Automated Screening Platform from Zinsser North America

Crissy Automated Screening Platform from Zinsser North America

Description

Polymorphism has become a concern in today’s pharmaceutical research laboratories as it affects a number of issues in pharmaceutical systems varying from processing characteristics to bioavailability. During the pre-formulation stage of drug development, polymorph screening is a tedious and time-consuming process.

Zinsser Analytic has developed CRISSY, an automated liquid and powder handling platform for salt pre-screening and polymorph screening studies. This platform automates the necessary steps for extensive crystallization using different solvents, temperatures, concentrations, agitation and pH-measurement. A special CRISSY® reactor block has been designed to directly present the crystals to the XRPD system without any additional sampling steps. The surface of the reactor base is ideal for XRPD-detection. Cross contamination caused by electrostatic force from moving the powders is minimized as the detector block itself is grounded and the individual reactor cavities are separated from each other in the “up” position.

Proven reliable X,Y,Z-platform with 4 independent Z-drives for liquid and powder handling and an integrated robotic arm for gripping vials, tubes, plates and pick-up tools, which can then be placed in any position of the workbench area.
Unique new hardware approach The precision balance is positioned outside the workbench still within reach of the robotic arm. The balance stand avoids any mechanical distortion, minimizing the settling time, improving the sensitivity and therefore increasing the throughput.
Designed for customization To meet individual requirements, it can be equipped with vortexers, hotplates, cooling plates, stirrers, reactor blocks, incubators or other modules from our extensive range of tools. The unique software allows the customer to even integrate his own modules. For special applications we offer the service of integration of custom modules.

For Crissy a special reactor system has been developed. The reactor consists of an aluminum carrier with 96 PTFE-inserts (reusable and cleanable in an ultra sonic bath) and adjustable bases with a glass disc on top.

The reactors can be sealed with the seals and sandwich plates of the “DESYRE®”-reactor system. The ELAS®-mat or SILTEF®-mat (PTFE coated) with 96 cross-slitted sealing rings are highly recommended as the first seal on top of the reaction cavities. An aluminum top plate secures the cross-slitted "dimplemats", hold down by thumbscrews for easy opening and closing. If necessary, further sealing layers can be added, also an inert gas shield can be added. For long term incubation – where the pierced sealing mats may cause evaporation of the solvents in the reactors – a solid seal can replace the septum seals. Crissy® reactors are also available for automatic sealing, an automatic lidding station can be provided as an option.

  • Detailed Specifications
  • ItemCrissy Automated Screening Platform
  • CompanyZinsser North America
  • PriceInquire
  • Catalog NumberCrissy
  • VolumeInquire
  • QuantityEA
  • Sample TypeLiquid and Powder
  • Channels4 Channels
  • Robotic Arm(s)1 Arm
  • Syringe SizesInquire
  • ApplicationsDrug Development, Screening Studies
  • Sample Weight2 to 10 mg (or 10 to 200 mg) Powder Pipettes
Zinsser North America
Zinsser North America
19145 Parthenia Street, Suite C
Northridge, CA 91324
United States
Phone: (818) 341-2906