Monday, February 17, 2014
Did you ever wonder just how would your dependable lab equipment—or your smartphone, for that matter—function in, say, Antarctica? Or even just blocks from your home or lab? How long would your smartphone or tablet last if it were accidentally left outside, braving the elements for days at a time?
Thursday, September 05, 2013
A particle size analyzer, also known as a particle sizer, is used to measure the sizes of particles in a sample. It can also determine distributions of particle sizes.
For fields that rely on liquid chromatography,
the standard today is usually ultra
high-performance liquid chromatography
(UHPLC). And with good reason—compared
to its chromatography predecessors, UHPLC is
faster, provides better separation, and requires
less reagents for operation. A steady evolution
of new instrument models over the past 10 years
means that today you can find a UHPLC system
with a variety of features to support your lab’s
work. Below are some basic guidelines for the
range of UHPLC instruments available today, as
well as purchasing considerations.
Thermal cyclers, also known as PCR machines or thermocyclers, are essential for any laboratory that relies on molecular biology. An indispensable tool for DNA amplification, the thermal cycler often
becomes a nonstop workhorse that lab workers
expect to function properly and efficiently.
Wednesday, April 24, 2013
Ultracentrifuges are a type of centrifuge designed to rotate samples at “ultrahigh” speeds (much higher than conventional centrifuges), with a rotational speed of up to 150,000 rpm, creating a centrifugal force up to more than 1 million × g. All
centrifuges can separate species within a liquid
according to density, but the high centrifugal
acceleration of ultracentrifuges lets you focus
in on those tiny differences among molecules
like proteins or nucleic acids.
Capillary electrophoresis (CE) systems are powerful instruments that can separate proteins, nucleic acids, or other species from a mixture quickly, with great accuracy and a relatively small investment of researcher time. CE and its cousin, gel electrophoresis, both separate molecules
according to charge and size, sometimes referred to as a molecule’s electrophoretic mobility.
Monday, February 18, 2013
Solid phase extraction (SPE) is a liquid chromatography method of separating a particular compound, or analyte, from a liquid mixture in which it is dissolved or suspended. This is commonly performed when separating an
analyte of interest from other impurities in a mixture, for example, in order to use the resulting sample (now more concentrated, and with greater purity) for further analytical or quantitative studies
such as mass spectrometry.
Friday, February 15, 2013
The ability to sort individual cells quickly based on their size or protein expression has had a significant, positive impact on any area of cell biology research or medicine in which a mixed population of cells needs to be sorted out. This is accomplished using flow cytometry, in which cells (or particles) in suspension are funneled single-file
through a narrow opening that ends in a nozzle, such that droplets of fluid emerge one at a time. Each droplet may, or may not, contain one cell.
X-ray diffraction—analyzing the diffraction patterns that result when a beam of X-rays scatters off of atoms in a crystal structure—is a powerful tool for studying molecular structure. Analyzing the specific angles of the diffracted X-rays, as well as their intensities, allows scientists to ascertain the size and shape of the molecules in the crystal, the atoms within those molecules, and their spatial arrangements and bonds. X-ray diffraction is valuable in many fields, having been used to determine molecular structures for the design of therapeutic drugs, and to understand the bonds and folds in three-dimensional protein structures. X-ray diffraction is also important for the structural analysis of many types of molecules, thin film analysis, examining crystal phase and structure, and sample stress and strain.
Wednesday, November 14, 2012
Micromanipulators are devices intended to translate macroscopic movements of the human hand into microscopic movements of a fine tool held in its grasp.
Thursday, September 06, 2012
Titration is the process of determining
the concentration of a chemical substance in a sample.
Laminar flow hoods fall in to two basic categories: biological safety cabinets (or biosafety cabinets) and laminar flow clean benches. These categories differ in the level of protection provided to the user, the sample, and the environment. Laminar flow h
Most laboratories would grind to a halt without the fundamental measurements provided by electrochemistry and weighing instruments.