Total Organic Carbon Analyzer (TOC Analyzers)

A total organic carbon analyzer (also referred to as TOC analyzers) measures the amount of total organic carbon present in a liquid or water sample. TOC detection is important because of the effects that TOCs may have on health, not to mention the environmental effects and implications for the pharmaceutical manufacturing processes. Since all total organic carbon analyzers only measure total carbon, a TOC analyzer always requires some accounting for the inorganic carbon (IC) that is always present. TOC analyzers, including a portable TOC analyzer, utilize the same basic technique where acid is added to the liquid sample to remove IC. At this point, the IC is converted into carbon dioxide gas. It is then stripped out of the liquid by a carrier gas where the remaining inorganic carbon-free sample is then oxidized and the carbon dioxide generated from the oxidation process is directly related to the TOC total organic carbon in the sample. There are several methods for introducing the sample to TOC analyzers, including using a syringe, autosampler, and loop sampling. An important specification for total organic carbon analyzers is the measuring range. Carrier gas flow rate, average analysis time and process temperature are important as well for total organic carbon analysis.

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  • Measurement Mode(s): Sulfur, Carbon
  • Oxidation Method: Thermal Combustion
  • Measuring Range: Varies with sample
  • Detection Limit: 0.05 to 5 ug (carbon), 0.05 to 1 ug (sulfur)
  • Measuring Time: 40 to 50 sec or 60 to 120 sec
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  • Measurement Mode(s): Sulfur, Carbon
  • Oxidation Method: Thermal Combustion
  • Measuring Range: 25 to 500 mg (carbon), 10 to 100 mg (sulfur)
  • Detection Limit: 5 ug (carbon), 1 ug (sulfur)
  • Measuring Time: 60 to 120 s
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CheckPoint Portable/On Line TOC Sensor

CheckPoint Portable/On Line TOC Sensor

GE Analytical Instruments

  • Measurement Mode(s): TOC
  • Oxidation Method: Inquire
  • Measuring Range: 0.21 ppb to 1000 ppb (CheckPoint Pharma) or 0.05 to 1000 ppb (CheckPointe)
  • Detection Limit: < 1% RSD or 0.21/0.05 ppb (on-line) and 3.0% RSD (at 500 ppb for grab samples)
  • Measuring Time: 15 sec to 8 hrs (on-line mode) or 10 min (grab mode)
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Sievers 500 RL On-Line TOC Analyzer

Sievers 500 RL On-Line TOC Analyzer

GE Analytical Instruments

  • Measurement Mode(s): TOC, TC and IC
  • Oxidation Method: Inquire
  • Measuring Range: 0.03 to 2500 ppb (as C)
  • Detection Limit: < 1% rsd or 0.03 ppb (as c)
  • Measuring Time: Continuous Mode: 6 min; Average and Timed Modes: 0.5, 1, 4, 8 or 24 hrs
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Sievers 500 RLe On-Line TOC Analyzer

Sievers 500 RLe On-Line TOC Analyzer

GE Analytical Instruments

  • Measurement Mode(s): TOC
  • Oxidation Method: Inquire
  • Measuring Range: 0.03 to 2500 ppb (as C)
  • Detection Limit: < 1% rsd or 0.03 ppb (as c)
  • Measuring Time: Continuous Mode: 6 min; Average and Timed Modes: 0.5, 1, 4, 8 or 24 hrs
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Sievers InnovOx Laboratory TOC Analyzer

GE Analytical Instruments

  • Measurement Mode(s): TC, TIC, TOC (TC-TIC) and NPOC
  • Oxidation Method: Supercritical Water Oxidation (SCWO)
  • Measuring Range: 0.5 to 50,000 ppm
  • Detection Limit: < 5% RSD (reading at 50 ppm NPOC)
  • Measuring Time: 2.6 to 9.2 min (depending on mode)
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Sievers InnovOx On-Line TOC Analyzer

Sievers InnovOx On-Line TOC Analyzer

GE Analytical Instruments

  • Measurement Mode(s): TC, TIC, TOC and NPOC
  • Oxidation Method: Supercritical Water Oxidation (SCWO)
  • Measuring Range: 0.5 to 50,000 ppm
  • Detection Limit: < 5% RSD (reading at 50 ppm NPOC)
  • Measuring Time: 2.6 to 8.3 min (online mode)
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Sievers M5310 C Laboratory Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): TOC analysis
  • Oxidation Method: Inquire
  • Measuring Range: 4 ppb to 50 ppm
  • Detection Limit: Inquire
  • Measuring Time: 2 min
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Sievers M5310 C On-Line Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): TOC analysis
  • Oxidation Method: Inquire
  • Measuring Range: 4 ppb to 50 ppm
  • Detection Limit: Inquire
  • Measuring Time: 2 min
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  • Measurement Mode(s): TOC Levels, Electrical Conductivity
  • Oxidation Method: UV/persulfate oxidation method
  • Measuring Range: 4 ppb to 50 ppm
  • Detection Limit: Inquire
  • Measuring Time: 2 mins
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Sievers M9 Laboratory Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): TOC Levels, Electrical Conductivity
  • Oxidation Method: UV/persulfate oxidation method
  • Measuring Range: 0.03 ppb to 50 ppm
  • Detection Limit: Inquire
  • Measuring Time: 2 min
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Sievers M9 On-Line Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): TOC Levels, Electrical Conductivity
  • Oxidation Method: UV/persulfate oxidation method
  • Measuring Range: 0.03 ppb to 50 ppm
  • Detection Limit: Inquire
  • Measuring Time: 2 min
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Sievers M9 Portable Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): Sample Conductivity, TOC Levels
  • Oxidation Method: UV/persulfate oxidation method
  • Measuring Range: Inquire
  • Detection Limit: Inquire
  • Measuring Time: 2 mins (Stage 1 analysis)
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ADI 7010 TOC On-Line Analyzer
  • Measurement Mode(s): Inquire
  • Oxidation Method: Inquire
  • Measuring Range: 0 to 50,000 mg/L
  • Detection Limit: 50,000 mg/L
  • Measuring Time: Inquire
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  • Measurement Mode(s): TC, NPOC, IC-POC M, TN
  • Oxidation Method: Combustion Oxidation / Non-Dispersive Infrared Gas Detection
  • Measuring Range: 5 to 20,000 mgC/L
  • Detection Limit: Inquire
  • Measuring Time: 4 min
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  • Measurement Mode(s): TC, IC, TOC and NPOC; (POC, TOC via POC + NPOC and TN : Optional)
  • Oxidation Method: Combustion Catalytic Oxidation Method (Non-Dispersive Infrared detection Method)
  • Measuring Range: TC: 0 to 30,000 mg/L, IC: 0 to 35,000 mg/L
  • Detection Limit: 4 or 50 ug/L (TC)
  • Measuring Time: 3 or 4 min
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TOC-VWS Wet Oxidation TOC Analyzer
  • Measurement Mode(s): TC, IC, TOC, NPOC
  • Oxidation Method: Wet Chemical (Heat-UV-Persulfate)
  • Measuring Range: TC: 0-3,500 mg/L, IC: 0-3,500 mg/L
  • Detection Limit: 0.5 µg/L
  • Measuring Time: ~ 4 minutes
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Fusion Total Organic Carbon (TOC) Analyzer
  • Measurement Mode(s): TOC (NPOC), TC- IC, TC, IC, (POC optional)
  • Oxidation Method: Photochemical Oxidation via UV-Persulfate
  • Measuring Range: 0.2 ppb to 4000 ppm
  • Detection Limit: 0.2 ppb
  • Measuring Time: 3 to 18 min (depending on type of analysis)
Inquire
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  • Measurement Mode(s): TOC (NPOC), TC-IC, TC, IC
  • Oxidation Method: High Temperature Combustion
  • Measuring Range: 50 ppb to 30,000 ppm (TOC), 50 ppb to 2000 ppm (TN)
  • Detection Limit: 50 ppb
  • Measuring Time: 5 to 30 min (depending on type of analysis)
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CM150 Carbon Analyzer
  • Measurement Mode(s): TC, TOC, TIC
  • Oxidation Method: High Temperature Combustion
  • Measuring Range: less than 1 ug to over 10,000 ug (carbon)
  • Detection Limit: Inquire
  • Measuring Time: 5 to 7 min
Inquire
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  • Measurement Mode(s): TC or TOC
  • Oxidation Method: High Temperature Combustion
  • Measuring Range: less than 1 ug to over 10,000 ug
  • Detection Limit: Inquire
  • Measuring Time: 5 to 7 min
Inquire
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Total Carbon, Total Inorganic Carbon, and Total Organic Carbon Auto-Analyzer
  • Measurement Mode(s): TC, TOC, TIC
  • Oxidation Method: High Temperature Combustion
  • Measuring Range: less than 1 ug to over 10,000 ug (carbon)
  • Detection Limit: Inquire
  • Measuring Time: 5 to 15 min
Inquire
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  • ELTRA GmbH
  • GE Analytical Instruments
  • Metrohm USA
  • Shimadzu
  • Teledyne Tekmar
  • UIC, Inc.

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