Dynamic Light Scattering Particle Size Analysis (DLS)

Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.

Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.

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Nicomp N3000 Online System
Entegris
  • Particle Size:
    Inquire
  • Measuring Time:
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WyattQELS&#8482; Light Scattering Detector Module
Waters | Wyatt Technology
  • Particle Size:
    Flow mode: 1 nm to 40 nm (TREOS); 1 nm to 300 (HELEOS)
    Batch mode: 10 to 50 nm; 0.5 nm to 1 µm (cut 10 to 50 nm)
  • Measuring Time:
    Measurement Time: 0.1 to 3600 sec
    Same as MALS host instrument
  • Light Source:
    Uses the host MALS instrument's laser, usually a 658 nm laser.
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DynaPro&trade; Plate Reader III Dynamic Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.5 to 1000 nm
  • Measuring Time:
    Measurement Time: 5 to 60 seconds per well
    830 nm
  • Light Source:
    830 nm, fiber-coupled diode laser
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Zetasizer Pro Particle Size Analyzer
Malvern Panalytical
  • Particle Size:
    0.3 nm to 10 µm (diameter)2
  • Measuring Time:
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  • Light Source:
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Citations:
(59)
DynaPro&trade; NanoStar&trade; II Dynamic Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.2 to 1000 nm
  • Measuring Time:
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  • Light Source:
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Mini DLS System
Entegris
  • Particle Size:
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  • Measuring Time:
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DynaPro&trade; ZetaStar&trade; Dynamic, Electrophoretic, and Static Light Scattering Instrument
Waters | Wyatt Technology
  • Particle Size:
    0.2 to 1000 nm
  • Measuring Time:
    15 seconds typical
  • Light Source:
    785 nm laser, programmable 10% to 100%
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