Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.
Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.
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Malvern Panalytical
- 0.3 nm to 10 µm (diameter)2
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Bettersize Instruments Ltd.
- 0.3nm - 15µm
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Waters | Wyatt Technology
- Flow mode: 1 nm to 40 nm (TREOS); 1 nm to 300 (HELEOS)
Batch mode: 10 to 50 nm; 0.5 nm to 1 µm (cut 10 to 50 nm) - Measurement Time: 0.1 to 3600 sec
Same as MALS host instrument - Uses the host MALS instrument's laser, usually a 658 nm laser.
Waters | Wyatt Technology
- 0.5 to 1000 nm
- Measurement Time: 5 to 60 seconds per well
830 nm - 830 nm, fiber-coupled diode laser
Malvern Panalytical
- 0.3 nm to 10 µm (diameter)2
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Waters | Wyatt Technology
- 0.2 to 1000 nm
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Waters | Wyatt Technology
- 0.2 to 1000 nm
- 15 seconds typical
- 785 nm laser, programmable 10% to 100%
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