Time of Flight Mass Spectrometer (TOF MS)

Time-of-flight mass spectrometers (TOF MS) do exactly what their name suggests: determine an ion’s mass-to-charge ratio (m/z) based on how long it takes for that ion to travel down the instrument’s “flight tube” and reach the detector. Frequently, though not exclusively coupled to matrix-assisted laser desorption ionization (MALDI) sources, TOF MS come in a variety of configurations, including a single-stage time-of-flight mass spectrometer, a multi-stage TOF/TOF, and even a hybrid quadrupole-TOF (Q-TOF) instrument; the latter two enable MS/MS applications. Often, time-of-flight mass spectrometers contain two detectors: a linear detector at the end of the flight tube, and a “reflector” detector, which captures ions that were redirected back towards the source by a “reflectron.” The reflectron serves two purposes: correcting for discrepancies in initial kinetic energy of identically sized molecules (which would cause them to reach the detector at different times and thus, have different apparent m/z values) and lengthening the flight path, improving resolution.

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6200 Series Accurate-Mass Time-of-Flight (TOF) LC/MS
  • Ionization Method(s): Electrospray (ESI)
  • Mass Analyzer: Time of Flight
  • Resolution: > 20,000 Resolving Power
  • Mass Range: 20 to 20,000 m/z
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6500 Series Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS
  • Ionization Method(s): ESI, APCI, APPI and MALDI
  • Mass Analyzer: Quadrupole Time of Flight (QTOF)
  • Resolution: up to 40,000 Mass Resolution (depending on model)
  • Mass Range: m/z 20 to 20,000
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BenchTOF-dx Time-of-Flight (TOF) Mass Spectrometer
  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: TOF
  • Resolution: Mass resolution: >1200 (FWHM) over 1-1000 Dalton
  • Mass Range: 1-1000 Dalton standard, 1-1500 Dalton optional
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Citius LC-HRT (High Resolution TOFMS)
  • Ionization Method(s): API, ESI, APCI and DESI
  • Mass Analyzer: TOF
  • Resolution: 2500, 50,000, or 100,000 FWHM
  • Mass Range: m/z Range
    Ultra-High Resolution Mode: Selected 4:1 range (e.g. 300 to 1200)
    High Resolution Mode: 50 to 2500
    Nominal Resolution Mode: 50 to 2500
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Pegasus 4D GCxGC-TOFMS
  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: Time of Flight (TOF)
  • Resolution: Inquire
  • Mass Range: Inquire
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Pegasus GC-HRT High Resolution TOFMS
  • Ionization Method(s): Electron Ionization
  • Mass Analyzer: Time of Flight
  • Resolution: up to 50,000 FWHM
  • Mass Range: Inquire
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Pegasus High Throughput TOF-MS
  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: Time of Flight (TOF)
  • Resolution: Inquire
  • Mass Range: Inquire
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Axima Assurance MALDI Time of Flight Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: >5000 FWHM
  • Mass Range: 1 kDa to 500 kDa
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Axima Confidence MALDI TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 5000 FWHM in linear mode; 15000 FWHM in reflectron mode
  • Mass Range: 1 kDa to 500 kDa
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Axima Performance MALDI TOF TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: >20,000 FWHM (Reflectron mode)
  • Mass Range: 1 kDa to 500 kDa
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AXIMA Resonance MALDI Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: QIT TOF
  • Resolution: up to 1000 FWHM
  • Mass Range: 100 to 12000 Da
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LCMS-IT-TOF Hybrid Mass Spectrometer
  • Ionization Method(s): APCI or ESI
  • Mass Analyzer: MS/MS: Ion Trap/TOF
  • Resolution: > 1,000 at 1,000 m/z
  • Mass Range: Inquire
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MegaTOF Megadalton MALDI Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 180 to 200 kDa
  • Mass Range: 0.01 to 1.5 Mda
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autoflex III Series MALDI-TOF & TOF/TOF Systems
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF or TOF/TOF
  • Resolution: > 20,000
  • Mass Range: 700 to 5000 Da
Inquire
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microflex Series Benchtop MALDI-TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
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micrOTOF II Electrospray Ionization Mass Spectrometer
  • Ionization Method(s): ESI, ESI-nano, APCI, APPI
  • Mass Analyzer: TOF
  • Resolution: >16,500 FWHM
  • Mass Range: 100 to 1000 Da
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micrOTOF-Q II Electrospray Ionization Mass Spectrometer
  • Ionization Method(s): ESI
  • Mass Analyzer: Qq-TOF
  • Resolution: 17,500 to 20,000 FWHM
  • Mass Range: 20 to 40,000 m/z
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ultrafleXtreme Series MALDI TOF/TOF Mass Spectrometers
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: > 40,000
  • Mass Range: Inquire
Inquire
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MassARRAY Analyzer 4

MassARRAY Analyzer 4

Sequenom, Inc.

  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
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FasTOF GC x GC x HiResTOFMS

FasTOF GC x GC x HiResTOFMS

Zoex Corporation

  • Ionization Method(s): Electron Impact Ionization
  • Mass Analyzer: Time of Flight (TOF)
  • Resolution: up to 5000
  • Mass Range: Inquire
Inquire
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