Time of Flight Mass Spectrometer (TOF MS)

Time-of-flight mass spectrometers (TOF MS) do exactly what their name suggests: determine an ion’s mass-to-charge ratio (m/z) based on how long it takes for that ion to travel down the instrument’s “flight tube” and reach the detector. Frequently, though not exclusively coupled to matrix-assisted laser desorption ionization (MALDI) sources, TOF MS come in a variety of configurations, including a single-stage time-of-flight mass spectrometer, a multi-stage TOF/TOF, and even a hybrid quadrupole-TOF (Q-TOF) instrument; the latter two enable MS/MS applications. Often, time-of-flight mass spectrometers contain two detectors: a linear detector at the end of the flight tube, and a “reflector” detector, which captures ions that were redirected back towards the source by a “reflectron.” The reflectron serves two purposes: correcting for discrepancies in initial kinetic energy of identically sized molecules (which would cause them to reach the detector at different times and thus, have different apparent m/z values) and lengthening the flight path, improving resolution.

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  • Ionization Method(s): Electrospray (ESI)
  • Mass Analyzer: Time of Flight
  • Resolution: > 20,000 Resolving Power
  • Mass Range: 20 to 20,000 m/z
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  • Ionization Method(s): ESI, APCI, APPI and MALDI
  • Mass Analyzer: Quadrupole Time of Flight (QTOF)
  • Resolution: up to 40,000 Mass Resolution (depending on model)
  • Mass Range: m/z 20 to 20,000
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RapidFire 365 High-throughput MS System
  • Ionization Method(s): Inquire
  • Mass Analyzer: Time of Flight (TOF) or Quadrupole Time of Flight (QTOF)
  • Resolution: Inquire
  • Mass Range: Inquire
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autoflex™ Series MALDI-TOF & TOF/TOF Systems
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF or TOF/TOF
  • Resolution: > 20,000
  • Mass Range: 700 to 5000 Da
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microflex Series Benchtop MALDI-TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
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micrOTOF II Electrospray Ionization Mass Spectrometer
  • Ionization Method(s): ESI, ESI-nano, APCI, APPI
  • Mass Analyzer: TOF
  • Resolution: >16,500 FWHM
  • Mass Range: 100 to 1000 Da
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micrOTOF-Q III Electrospray Ionization Mass Spectrometer
  • Ionization Method(s): ESI
  • Mass Analyzer: Qq-TOF
  • Resolution: 20,000 FWHM
  • Mass Range: 2ppm mass accuracy, low picogram sensitivity
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ultrafleXtreme™ Series MALDI Series MALDI TOF/TOF Mass Spectrometers
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: Up to 40,000
  • Mass Range: Inquire
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Pegasus 4D GCxGC-TOFMS
  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: Time of Flight (TOF)
  • Resolution: Inquire
  • Mass Range: Inquire
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Pegasus GC-HRT High Resolution TOFMS
  • Ionization Method(s): Electron Ionization
  • Mass Analyzer: Time of Flight
  • Resolution: up to 50,000 FWHM
  • Mass Range: Inquire
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  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: Time of Flight (TOF)
  • Resolution: Inquire
  • Mass Range: Inquire
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  • Ionization Method(s): Electron Ionization (EI)
  • Mass Analyzer: TOF
  • Resolution: Mass resolution: > 1200 (FWHM) over 1 to 1000 Dalton
  • Mass Range: 1 to 1000 Dalton standard, 1 to 1500 Dalton optional
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Select-eV® Revolutionary Variable-Energy Ion-Source Technology for GC–MS
  • Ionization Method(s): Electron Ionisation
  • Mass Analyzer: Time of Flight
  • Resolution: Inquire
  • Mass Range: Inquire
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Axima Assurance MALDI Time of Flight Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: >5000 FWHM
  • Mass Range: 1 kDa to 500 kDa
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Axima Confidence MALDI TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 5000 FWHM in linear mode; 15000 FWHM in reflectron mode
  • Mass Range: 1 kDa to 500 kDa
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Axima Performance MALDI TOF TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: >20,000 FWHM (Reflectron mode)
  • Mass Range: 1 kDa to 500 kDa
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AXIMA Resonance MALDI Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: QIT TOF
  • Resolution: up to 1000 FWHM
  • Mass Range: 100 to 12000 Da
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LCMS-IT-TOF Hybrid Mass Spectrometer
  • Ionization Method(s): APCI or ESI
  • Mass Analyzer: MS/MS: Ion Trap/TOF
  • Resolution: > 1,000 at 1,000 m/z
  • Mass Range: Inquire
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MALDI-7090 TOF Mass Spectrometer
  • Ionization Method(s): Inquire
  • Mass Analyzer: 10 000 FWHM
  • Resolution: Inquire
  • Mass Range: Inquire
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  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 180 to 200 kDa
  • Mass Range: 0.01 to 1.5 Mda
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MassARRAY Analyzer 4

MassARRAY Analyzer 4

Sequenom, Inc.

  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
Inquire
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Other Companies that sell Time of Flight Mass Spectrometer (TOF MS)

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  • Agilent Technologies
  • Bruker Daltonics
  • LECO
  • Markes International Ltd
  • Sequenom, Inc.
  • Shimadzu

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