Maldi TOF Mass Spectrometer (MALDI TOF MS)

MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.

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VITEK® MS MALDI-TOF Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: 1 to 500 kDa
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autoflex™ Series MALDI-TOF & TOF/TOF Systems
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF or TOF/TOF
  • Resolution: > 20,000
  • Mass Range: 700 to 5000 Da
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microflex Series Benchtop MALDI-TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
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ultrafleXtreme™ Series MALDI Series MALDI TOF/TOF Mass Spectrometers
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: Up to 40,000
  • Mass Range: Inquire
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Axima Assurance MALDI Time of Flight Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: >5000 FWHM
  • Mass Range: 1 kDa to 500 kDa
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Axima Confidence MALDI TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 5000 FWHM in linear mode; 15000 FWHM in reflectron mode
  • Mass Range: 1 kDa to 500 kDa
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AXIMA Glycan Analyzer
  • Ionization Method(s): Inquire
  • Mass Analyzer: MALDI-QIT TOF
  • Resolution: > 1000 FWHM
  • Mass Range: Inquire
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Axima Performance MALDI TOF TOF Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF/TOF
  • Resolution: >20,000 FWHM (Reflectron mode)
  • Mass Range: 1 kDa to 500 kDa
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AXIMA Resonance MALDI Mass Spectrometer
  • Ionization Method(s): MALDI
  • Mass Analyzer: QIT TOF
  • Resolution: up to 1000 FWHM
  • Mass Range: 100 to 12000 Da
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AXIMA-iD Plus Microorganism Analysis
  • Ionization Method(s): Inquire
  • Mass Analyzer: MALDI-TOF MS
  • Resolution: Inquire
  • Mass Range: Inquire
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MALDI-7090 TOF Mass Spectrometer
  • Ionization Method(s): Inquire
  • Mass Analyzer: 10 000 FWHM
  • Resolution: Inquire
  • Mass Range: Inquire
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  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: 180 to 200 kDa
  • Mass Range: 0.01 to 1.5 Mda
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MassARRAY Analyzer 4

MassARRAY Analyzer 4

Sequenom, Inc.

  • Ionization Method(s): MALDI
  • Mass Analyzer: TOF
  • Resolution: Inquire
  • Mass Range: Inquire
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  • bioMérieux, Inc.
  • Bruker Daltonics
  • Sequenom, Inc.
  • Shimadzu

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