A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in either SIM or scan mode. The method can be used to obtain structural information or for quantitation. For structural mass spec, a common sequence is product ion scan, precursor ion scan, and neutral loss scan, followed by selected reaction monitoring (SRM) or multiple reaction monitoring (MRM).
Increased selectivity, improved S/N, lower limits of quantitation, wider linear range, and improved accuracy are some of the benefits of this technique, which encompasses triple-quad LC-MS, GC-MS, GC-MSD, and ICP-MS. Although QqQ is a particularly useful method for all stages of pharmaceutical development, it is a reliable option for many applications, such as clinical research, food safety, forensics, environmental, and proteomics.
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Company | Shimadzu |
Item | LCMS-8050 Triple Quadrupole LC/MS/MS Mass Spectrometer |
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Catalog Number | LCMS-8050 |
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Description | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.. Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Newly developed heated ESI probe facilitates ionization – allows for high-sensitivity analysis of a wide range of compounds
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements. In addition, optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.... Read More |
Ionization Method(s) | ESI, APCI, Dual Ionization |
Mass Analyzer | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods |
Mass Range | 2 to 2000 m/z |
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