Description
Alzheimer's Disease (AD) is characterized by the presence of extracellular senile plaques (SPs) and intracellular neurofibrillary tangles (NFT) in the brain. The major protein component of SPs is beta Amyloid peptide (AB) 40 AND 42(43). AB 42 is more prone to aggregate than AB 40. Therefore the initial AB deposition begins with AB 42(43) but not with AB 40. AB 42(43)-positive and AB 40-negative plaques may represent early-stage diffuse type SPs, and AB 40-positive plaque appears in the advanced stage, especially more often in the cored portion of the mature plaque.The improved (II) kits achieve more stable antigen-antibody reaction by using F(ab')2 fragment of the labeled antibody BA27, which recognizes the C-terminal of AB40, while the nonspecific binding is reduced. Therefore, the stability in the washing solution is improved.