Description
A54556A is an unusual depsipeptide isolated from:Streptomyces:sp., featuring a trienone side chain. It is potently active against Gram positive and Gram negative bacteria, including MRSA. A54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria