Olympus Corporation offers the Alpha³ light sheet microscope, the result of a new partnership with 3-D microscopy and scientific imaging company PhaseView. Combining the Olympus BX43 upright frame and optics with PhaseView’s advanced multiview selective plane illumination technology, the Alpha³ is a cost-effective light microscopy solution. The Alpha³ light sheet microscope system provides high temporal and spatial resolution of both fixed and live biological samples for 3-D imaging. Optional Smart 3-D scanning technology allows for fast z-stacking and perturbation-free acquisition at 75 images/second. Unlike traditional confocal technologies, which experience a drop in brightness with increasing depth, light sheet offers a greater depth of field over the entire field of view. Due in part to its dual illumination units, the Alpha³ can provide greater subcellular resolution without compromising the speed or excitation efficiency.