Dynamic Light Scattering Particle Size Analysis (DLS)

Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.

Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.
CompanyWaters | Wyatt TechnologyWaters | Wyatt Technology
ItemDAWN™ Multi-angle Light Scattering (MALS) InstrumentDynaPro™ NanoStar™ II Dynamic Light Scattering Instrument
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Catalog NumberDAWNDynaPro NanoStar II
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DescriptionThe DAWN™ instrument is an advanced detector for precise characterization of proteins, polymers, and nanoparticles including viral vectors, lipid nanoparticles and vesicles. Using multi-angle static light scattering (MALS) and optional dynamic light scattering (DLS), DAWN analyzes molar mass... Read MoreThe DynaPro™ NanoStar™ II is the only DLS instrument to provide a fully integrated, walk-up measurement experience so even novices can immediately measure particle concentration, characterize size, aggregation, quality solubility, and stability of proteins, viruses, or nanoparticles in ... Read More
TypeMALS and optional DLSDynamic Light Scattering (DLS) and Static Light Scattering (SLS)
Particle SizeInquire0.2 to 1000 nm
Detector(s)High-gain, high-dynamic-range photodiodes at 18 angles for MALS; optional avalanche photodiode that may be placed at any of four angles for DLS.
Fluorescence-blocking filters available for use with analytes that fluoresce when illuminated at the MALS wavelength.
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Measuring TimeDepedent on LC separationInquire
Light Source658 nm laser, programmable 10% - 100% of maximum power.

Optional: 785 nm for fluorescence suppression
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