Description
Solid phase sandwich ELISA (Enzyme-linked Immunosorbent Assay) for the determination of human total Tau in CSF. For research use only, not for use in diagnostic procedures.
Tau protein is a 45-50kDa microtubule-associated protein that consists of 352-441 amino acids. It has the role of stabilizing microtubules that transport intracellular substances in nerve cells. It is known that tauopathy such as Alzheimer's type dementia (AD) and frontotemporal lobar degeneration (FTLD) is developed due to abnormal accumulation of Tau. Three features of AD, senile plaque, neurofibrillary tangle, and neuronal cell death have been observed in the brain of AD subjects and it is considered that neurofibrillary tangle is triggered by abnormal accumulation of Tau.