Description
Cilastatin- 15 N,d 3 is a 15 N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 µM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 µM. Cilastatin is an antibacterial adjunct.In VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid