Description
2-Chlorobenzimidazole can be synthesized by reacting benzimidazole-2-one with phosphoryl chloride in the presence of phenol；Application：2-Chlorobenzimidazole can be used to synthesize the following:1-methyl-2-chlorobenzimidazole via reaction with dimethyl sulfate；1-ethyl-2-chlorobenzimidazole via reaction with diethyl sulfate；1-benzyl-2-chlorobenzimidazole via reaction with benzyl chloride；2-chloro-4,5,6,7-tetrabromobenzimidazole via bromination with bromine；It may be used as a building block to synthesize 4-amino-6-benzimidazole-pyrimidines；