Description
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases 45 Ca 2+ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.In Vitroβ-Amyloid (1-40) (rat) (1 µM; 1 h) increases 45 Ca 2+ influx and elevates Ca 2+ in cortical synaptosomes. β-Amyloid (1-40) (rat) (3 nM) induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield and induces apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivoβ-Amyloid (1-40) (rat) (1.7 mg; ICV, for 7 d; swiss and C57BL/6 mice) induces the learning and memory deficits in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Swiss and C57BL/6 miceDosage: 1.7 mg Administration: Intracerebroventrical injection; for 7 days Result: Presented spatial learning and memory impairments.Form:Solid