Description
Triisopropylsilane is a highly selective reducing agent which can be used to prepare anti-1,2-diols.The bulky isopropyl groups (vs. ethyl) allow for more selective reductions, e.g., beta-selective reduction of anomeric C-phenyl ketals, but do not diminish their activity (e.g. in the copper triflate catalyzed reductive etherification of trimethylsilyl ethers). Used in a highly diastereoelective preparation of anti-1,2-diols catalyzed by a Ni(O) N-heterocyclic carbene complex