Description
DescriptionWhen used with aliphatic or aromatic aldehydes, this silicon amine protocolSLAP reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)2dtbbpy]PF6(747769) is used with a recommended starting combination of Lewis acids Bi(OTf)3(633305) and Cu(OTf)2(283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with theBode Research Groupand provides a tin-free alternative toSnAP(tin amine protocol) reagents and is well-suited for scale-up reactions