Description
(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC 50 s of 1.7 µM, 2.9 µM and 1.74 µM for JNK1, JNK2 and JNK3, respectivelyIn Vitro(−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs. (−)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:JNK1 1.7 µM (IC 50 ) JNK2 2.9 µM (IC 50 ) JNK3 1.74 µM (IC 50 )