Description
K252B: an inhibitor of protein kinase A, C, G K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 µM), PKA (cAMP- dependent protein kinase, Ki=0.09 µM), PKC (protein kinase C, Ki=0.02 µM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 µM).An antibiotic and a strong inhibitor of protein kinase C (PKC)