Description
(±)17-HDoHE is an autoxidation product of docosahexaenoic acid (DHA):in vitro:. It has been found to be produced from incubations of DHA in rat brain, intestinal microsomes and liver. (±)17-HDoHE has been shown to inhibit U-46619-induced rabbit and rat aortic smooth muscle contraction (IC:50:= 4.9 and 7.2 µM, respectively). It is also a potential marker of oxidative stress in brain and retina where DHA is abundant