2′,3′-Dihydro-7′-methyl-5′-oxo-spiro[1,3-dioxolane-2,1′(5′H)-indolizine]-6′-carbonitrile from Aladdin Scientific Corporation

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Aladdin Scientific Corporation for
2′,3′-Dihydro-7′-methyl-5′-oxo-spiro[1,3-dioxolane-2,1′(5′H)-indolizine]-6′-carbonitrile

Description

2',3'-Dihydro-7'-methyl-5'-oxo-spiro[1,3-dioxolane-2,1'(5'H)-indolizine]-6'-carbonitrile is used in the preparation of camptothecin (CPT) derivatives. CPT is a cytotoxic quinoline alkaloid which inhibits topoisomerase I (topo I). Topo I acts to cut one strand of double-stranded DNA, relax the strand, and reanneal the strands together.ApplicationsUsed in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents