Description
InformationND646 ND-646 is an allosteric inhibitor of the ACC (Acetyl-coA carboxylase) enzymes that prevents ACC subunit dimerization to suppress fatty acid synthesis with IC50 of 3.5 nM and 4.1 nM for hACC1 and hACC2, respectively.TargetshACC1 (Cell-free assay); hACC2 (Cell-free assay) 3.5 nM; 4.1 nMIn vitroND-646 inhibits FASyn in vitro and induces apoptosis in NSCLC cells. AMPK phosphorylation sites can be used as a biomarker to monitor ACC engagement by ND-646.In vivoChronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibits tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppresses lung tumor growth in the Kras;Trp53−/− (also known as KRAS p53) and Kras;Stk11−/− (also known as KRAS Lkb1) mouse models of NSCLC.Cell Research(from reference)Cell lines：A549 cells Concentrations：7 nM, 21 nM, 62 nM, 185 nM, 555 nM, 1666 nM, 5000 nM Incubation Time：24 hrs