Description
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC 50 value of 0.6 µM, competitively inhibits the affinity of DGKα for ATP with a K m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cellsForm:SolidIC50& Target:IC50: 0.6 µM (DGKα)