N-Ethyl-N-isopropylpropan-2-aminium 3-(4-Cyano-2,3,5,6-tetrafluorophenyl)-4-oxo-1,5-dioxaspiro[5.5]-undec-2-en-2-olate from Aladdin Scientific Corporation

DescriptionN-Ethyl-N-isopropylpropan-2-aminium 3-(4-cyano-2,3,5,6-tetrafluorophenyl)-4-oxo-1,5-dioxaspiro[5.5]-undec-2-en-2-olate is a fluoroarylated-meldrum′s acid adduct. It can be prepared by reacting cyclohexyl-Meldrum′s acid with 2,3,4,5,6-pentafluorobenzonitrile in the presence ofN,N-diisopropylethylamine and acetonitrile.This compound undergoes cycloreversion to form the fluoro(hetero)aryl ketene, which undergoes efficient coupling with nucleophiles and allows rapid incorporation of highly fluorinated α-fluoro(hetero)aryl acetic acid derivatives