Description
(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 µM with in vitro and in vivo efficacy.Appearance:SolidIn Vitro:(D)-PPA 1 TFA (0.2 mg/mL, 1.0 mg/mL) blocks the interaction between PD-1/PD-L1 at 1.0 mg/mL. (D)-PPA 1 TFA (3.125-100 µM; 24 h, 48 h) doesn’t kill tumor cells directly with no affect on CT26 cells growth. MCE has not independently confirmed theIn Vivo:(D)-PPA 1 TFA (2mg/kg; s.c. or i.p.; once daily for 7 d) inhibits CT26 tumor growth in vivo in mice. (D)-PPA 1 TFA (40 µg/mouse in 200 µL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice. MCE has not indeBiological Activity:(D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 µM with in vitro and in vivo efficacy