Description
Kolliphor® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).Application：Kolliphor® HS 15 has been used:in dissolving dexamethasone (DEX) to intraperitoneally inject the mice to test its grip strength to measure the muscle forcein roflumilast preparation to treat rabbits and guinea pigs to study the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responsesto dissolve finerenone for oral application in in vivo-studiesAdvantages and Features：Low histamine release for fewer side-effectsOffers thermal stability, suitable for heat sterilization Has lower hemolytic activity than other polyoxyethylene-based surfactants Allows to formulate poorly soluble APIs in oral and parenteral dosage forms