Description
(±)11-HDoHE is an autoxidation product of docosahexaenoic acid (DHA) in vitro (1,2) and also produced from incubations of DHA in rat brain, intestinal microsomes and liver.3,4,5 DHA is metabolized to 11(S)-HDoHE by human platelets and canine retina.6,7,8,5 In addition to 11(S)-HDoHE, 14(S)-HDoHE is also produced by platelets. 11(S)-HDoHE was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5µM, respectively. It is a potential marker of oxidative stress in brain and retina where DHA is abundant