Description
Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa. In VitroTebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent K m and k cat values of 0.8 µM and 0.03 min -1, respectively. Tebipenem shows potent activity against B. pseudomallei, with MIC 50 and MIC 90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae, with the MIC range of ≤0.25 µg/mL in all of the S. pneumoniae isolates. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:β-lactam