Description
Kavain (+/-), a lipophilic kavapyrone, has been originally extracted from:Piper methysticum:. This compound has been shown to significantly antagonize dopamine depletion in murine striatal neurons. Additional studies report that Kavain (+/-) impairs vascular smooth muscle contraction via inhibition of Ca:+:channels, causing relaxation in precontracted murine ileum, airways, and aortic rings. Furthermore, at high concentrations, this agent has been noted to display neurotoxic characteristics