Description
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a K i of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulationIn Vitro(D-Trp12,Tyr34)-pTH (7-34) amide (0.05-10 µM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells. (D-Trp12,Tyr34)-pTH (7-34) amide (0.1-10 µM) attenuates inhibition of Nap i T promoted by 1 nM of either PTHrP or PTH. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo(D-Trp12,Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Ki: 69 nM (PTH)