Description
(±)5,6-DHET, or (±)5,6-dihydroxyeicosatetraenoic acid, cataloged under CAS number 213382-49-1, is a metabolite derived from the oxidative metabolism of arachidonic acid, specifically through the action of cytochrome P450 enzymes. This compound is part of a larger group of eicosanoids, which are oxidized derivatives of twenty-carbon fatty acids and play significant roles in various biochemical pathways. In research settings, (±)5,6-DHET is utilized to study the enzymatic pathways involved in the metabolism of arachidonic acid and to understand the role of cytochrome P450 enzymes in the generation of eicosanoids. This metabolite is particularly interesting because it provides insights into the non-enzymatic and enzymatic processes that regulate the levels and activity of eicosanoids, which are crucial for cellular signaling mechanisms that govern physiological responses. By studying (±)5,6-DHET, researchers can explore how cells respond to oxidative stress and how they regulate inflammatory processes at a molecular level. This research has significant implications for understanding the biochemical cascades that underpin various cellular behaviors and responses without directly focusing on therapeutic applications. Moreover, (±)5,6-DHET serves as a biochemical tool to assess the impact of oxidative enzymes on lipid signaling pathways, contributing to a deeper understanding of lipidomics and its relevance to cellular health and disease. Product DescriptionEpoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in vitro.Product Application(±)-5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic Acid ((±)5,6-DHET) is associated with abnormal lipoprotein oxylipins and metabolic disorders and may contribute to chronic inflammation