Description
Stannic chloride (SnCl 4 ) is a strong Lewis acid widely used as a promoter or catalyst in organic synthesis. It is soluble in most organic solvents.ApplicationStannic chloride can be used to catalyze: Cyclization of trans β-monocyclohomofarnesic acid to form norambreinolide. Formation of C-glycosides of aromatic compounds such as thiophene, naphthalene and phloroglucinol trimethyl ether. Formal [4+2] cycloaddition of 3-ethoxycyclobutanones and allyltrialkylsilanes to form 3-ethoxy-5-[(trialkylsilyl)methyl]cyclohexan-1-ones. Diastereoselective reaction of δ-alkoxyallylstannanes with aldehydes to form 1,5-diol derivatives. Other applications of SnCl 4 : The SnCl 4 -2,6-dialkoxyphenols complexes can catalyze cyclization of poylenes, such as 4-(homogeranyl)toluene to form trans -fused tricyclic compound. SnCl 4 can act as a promoter during the reaction of ortho -aminobenzonitriles with β-ketoesters and β-enaminonitriles to form 4-aminoquinolines and 4-aminopyridines, respectively. SnCl 4 -silver perchlorate forms an effective catalytic system for the stereoselective of glycosylation 1- O -acetyl glucose