Description
α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin 'bait' sequence, the macroglobulin rearranges and traps the protease