Description
A nonacidic, aminoalkylindole analgesic agent that inhibits COX; inhibits PG synthesis (IC50 = 5 µM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an ACh-induced writhing assay in mice); inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 µM)