Description
(1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride, and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca 2+ -induced accumulation of [ 3 H]inositol phosphate with an IC 50 of 0.39 µM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment