Description
(R,S,R)-ML334 is the isomer of ML334, and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K d of 1 µM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity