Description
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor ( α2A-AR ) with EC 50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED 50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes