Description
α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR ( Adrenergic receptor ) PROTAC degrader, with a DC 50 of 2.86 µM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC 50 of 6.12 µM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research