Description
(1R,3S)-Compound E is the isomer of Compound E, and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC 50 s of 0.24, 0.37, 0.32 nM, respectively