Description
AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 µM, 0.5 µM, and >3 µM, for PARP1, PARP2, and PARP6, respectively