(1S,2S)-ML-SI3 from MedChemExpress

(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 µM/10.8 µM) and a potent inhibitor of TRPML1 (IC50=5.9 µM)[1]