Description
(R)-CR8, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 µM), CDK2/cyclin A (0.072 µM), CDK2/cyclin E (0.041 µM), CDK5/p25 (0.11 µM), CDK7/cyclin H (1.1 µM), CDK9/cyclin T (0.18 µM) and CK1δ/ε (0.4 µM). (R)-CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3]