Description
(±)-BI-D is a potent ALLINI (allosteric integrase inhibitor). (±)-BI-D binds integrase at the LEDGF/p75 binding site. (±)-BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 µM in Psip1 knockout E9 mouse embryonic fibroblasts, 2.9 µM in wild-type E9 mouse embryonic fibroblasts)[1][2]