Description
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 µM, 0.57 µM, and 0.63 µM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1]