Description
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 µM and 3.72 µM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the study of pain[1]