Description
(E)-FOBISIN101 is a 14-3-3 protein inhibitor (14-3-3γ IC50 = 16.4 µM; 14-3-3ζ IC50 = 9.3 µM). (E)-FOBISIN101 inhibits the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase. (E)-FOBISIN101 can be used for 14-3-3-mediated cancer research[1]