Description
Hepatocytes (hepatocytes) are one of the most widely used cell types in research, drug development and toxicity testing. Existing liver models (for cell culture-based systems) include primary human hepatocytes harvested from donors, immortalized cell lines (such as HepG2) and cells from rodent models. Each of these models has experimental limitations. For example, studies have shown that the observed changes in liver cell function depend on the genotype and environmental background of each donor. Immortalized cell lines are widely used in research, but they suffer from various functional deficiencies, which are essential for evaluating the metabolism and toxicity of drug candidates. Therefore, iPSC-derived hepatocytes were developed to overcome the shortcomings found in traditional methods and systems.