Description
Rat microglia (RMcg) are extracted from the brains of normal rats on the first day after birth by standard methods. When resurrected under the recommended conditions, inoculated and cultured, RMcg forms an adherent culture.
Microglia originate from hematopoietic stem cells in the bone marrow and are resident macrophages in the central nervous system (CNS). Due to the presence of the blood-brain barrier, they are separated from the rest of the body. Microglia actively investigate the surrounding area and respond by removing damaged nerve cells, plaques and infectious agents. Since microglia have the function of immune response and maintenance of homeostasis in the central nervous system, they are related to neurodevelopment, central nervous system plasticity and repair, neuroinflammation, aging and neurodegeneration, neuropathic pain and infection.