Description
Inter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of the proteins is a function of bikunin, the common light chain of the IAIP.In acute inflammation, the lal acts as a negative acute-phase protein, whereas the Pal acts as a positive acute-phase protein. IaIp are being considered as biomarkers and biotherapies for metastatic disease, septic shock and complement system disorders.Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.Immunoblotting: Immunoreactive with anti-BikuninPrepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.For research use or for use in further manufacturing